Leukemia inhibitory factor regulates trafficking of T-type Ca2+ channels
نویسندگان
چکیده
منابع مشابه
Ion Trafficking through T-type Ca2+ Channels
Voltage-gated Ca 2 channels play a key role in controlling Ca 2 entry during cell depolarization. At least 10 genes encode the main ( 1 ) subunits of voltage-gated Ca 2 channels, which have been grouped into two main classes: the high voltage–activated (HVA) and the low voltage–activated (LVA) channels. HVA channels are primarily involved in muscle contraction, synaptic transmission, and hormon...
متن کاملT-type Ca2+ channels
Perhaps one of the most remarkable features of T-type calcium channels is their low-threshold of activation that makes these channels important candidates for calcium entry near the resting membrane potential of neurons. Hence, they mediate low-threshold burst discharges that occur during different forms of neuronal rhythmogenesis, but play also important roles in sensory transmission, as well ...
متن کاملPathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation.
Since conventional Ca(2+) antagonists, with predominant blockade of L-type voltage-dependent Ca(2+) channels, elicit preferential dilation of afferent arterioles, they might ostensibly aggravate glomerular hypertension. Recently, novel Ca(2+) antagonists, with inhibitory action on L-/T-type Ca(2+) channels, have been reported to dilate both afferent and efferent arterioles. The present review a...
متن کاملT-type Ca2+ channels in thalamic sensory gating and affective Disorders
Low threshold Ca2+ currents mediated by T-type channels underlie burst spike activities of relay neurons in the thalamus. We have previously reported that knock-out mice for T-type channels show an enhanced nociceptive response to visceral pain, accompanied by an increase in tonic spikes in the absence of burst spikes in thalamic relay neurons. These results raised a possibility that T-type cha...
متن کاملT-type Ca2+ channels in thalamic sensory gating and affective Disorders
Low threshold Ca2+ currents mediated by T-type channels underlie burst spike activities of relay neurons in the thalamus. We have previously reported that knock-out mice for T-type channels show an enhanced nociceptive response to visceral pain, accompanied by an increase in tonic spikes in the absence of burst spikes in thalamic relay neurons. These results raised a possibility that T-type cha...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2011
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00115.2010